Puromycin, CAS 53-79-2

Formulation: A solid

Formal Name: 3′-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-adenosine

Purity: ≥95%

Formula Markup: C22H29N7O5

Formula Weight: 471,5

Shelf life (days): 1460

CAS Number: 53-79-2

Notes: Puromycin is a derivative of the glomerular epithelial cell toxin puromycin aminonucleoside (Item No. 15509) and an inhibitor of protein synthesis that has been found in S. alboniger.{35949,21742,21743,21744,65901,42191} Puromycin is structurally similar to the amino acid-bearing end of tRNA, which allows it to enter the ribosome during protein synthesis, bind to the nascent polypeptide chain, and halt chain elongation.{21742,21743,21744} It inhibits protein synthesis by 99% in vitro.{65901} Puromycin is also an inhibitor of puromycin-sensitive aminopeptidase (PSA) and aminopeptidase N (APN; IC50s = 9.7 and 41 µM, respectively). It reduces the viability of HL-60 human promyelocytic leukemia and MOLT-4 human acute lymphoblastic leukemia cells (EC50s = 0.055 and 0.17 µM, respectively). Puromycin is active against the chloroquine-sensitive and -resistant P. falciparum strains T9-96 and K1 (IC50s = 0.024 and 0.023 µM, respectively).{42191} Puromycin has been used as a selective marker in cell culture systems and has been chemically modified for use in labeling or imaging newly synthesized proteins.{65902}

• Artikelnummer: CAY35841-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35841-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK