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Biological Activity: Quercetin has been shown to inhibit PDE 5A with an IC50 value of 1.9 µM.
CAS Number: 117-39-5
Description: Quercetin is an inhibitor of PDEs of both cAMP and cGMP. It is a flavonoid found in plant and fruit bark or rinds. It is estimated that normal dietary intake of Quercetin for humans is 0.1-0.2 mg/kg. Quercetin can induce renal adenomas in male rats when fed at 2,000 mg/kg.
Format: A crystalline solid
Purity: ≥95% by HPLC
Solubility: Soluble in ethanol, DMSO and DMF, purged with an inert gas. Solubility in ethanol is 2 mg/ml and solubility in DMSO and DMF is 30 mg/ml.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Gschwendt, M., et al., Biochem. Biophys. Res. Commun. 1983; 117(2): 444-447.
2. Young, J.F., et al., Am. J. Clin. Nutr. 1999; 69(1): 87-94.