RBN-012759, CAS 2360851-29-0

Formulation: A solid

Formal Name: 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-4(3H)-quinazolinone

Purity: ≥98%

Formula Markup: C19H23FN2O3S

Formula Weight: 378,5

Shelf life (days): 1460

CAS Number: 2360851-29-0

Notes: RBN-012759 is an inhibitor of poly(ADP-ribose) polymerase 14 (PARP14; IC50 = 0.003 µM).{69068} It is selective for PARP14 over PARP1-4, -5a, -5b, -6-12, -15, and -16 (IC50s = 1->100 µM). RBN-012759 (10 µM) inhibits IFN-γ-induced PARP14 auto-MARylation in CFPAC-1 cells. It inhibits IL-4-induced protumor M2-like macrophage polarization in isolated human primary macrophages. RBN-012759 (1 µM) also induces expression of the genes encoding the pro-inflammatory chemokines chemokine (C-C motif) ligand 13 (CCL13), CCL19, and chemokine (C-X-C motif) ligand 11 (CXCL11) in human kidney cancer tumor explants.

• Artikelnummer: CAY36137-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36137-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe