Ripasudil (hydrochloride hydrate), CAS 887375-67-9

Formulation: A crystalline solid

Formal Name: 4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-isoquinoline, monohydrochloride, dihydrate

Purity: ≥98%

Formula Markup: C15H18FN3O2S • HCl [2H2O]

Formula Weight: 395,9

Shelf life (days): 1460

CAS Number: 887375-67-9

Notes: Ripasudil is an inhibitor of Rho-associated kinase 1 (ROCK1) and ROCK2 (IC50s = 51 and 19 nM, respectively).{33217} It is selective for ROCK1 and ROCK2 over protein kinase A catalytic subunit α (PKACα) and PKC (IC50s = 2,100 and >10,000 nM, respectively). Ripasudil (0.4%) reduces intraocular pressure in cynomolgus monkey to a greater extent than the prostaglandin FP receptor agonist latanoprost (Item No. 16812). It increases the outflow facility of the aqueous humor in rabbit eyes when administered in a 0.4% solution. Ripasudil (0.4%) decreases intraocular pressure, retinal ganglion cell death, and thinning of inner retinal layers, as well as improves retinal function, in an excitatory amino acid transporter 1 (EAAT1) knockout mouse model of normal tension glaucoma.{51414} Formulations containing ripasudil have been used in the treatment of glaucoma and ocular hypertension.

• Artikelnummer: CAY19920-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 19920-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK