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S- (+)-Rolipram, CAS 85416-73-5
S- (+)-Rolipram, CAS 85416-73-5
Artikelnummer
BPS27648-1
Verpackungseinheit
10 mg
Hersteller
BPS Bioscience
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Background: Rolipram is a racemic drug that increases brain cAMP availability by inhibiting phosphodiesterase. The S-(+)-Rolipram enantiomer is 2-10x less potent than the R-(-)-Rolipram compound. PDE4B is involved in dopamine-associated and stress-related behaviours, and is believed to be the PDE4 subtype involved in the antipsychotic effects of PDE4 inhibitors such as rolipram.
CAS Number: 85416-73-5
Description: S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 µM. It has anti-inflammatory and anti-depressant activity in the central nervous system.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: PDE4B
Biosafety Level: Not applicable (BSL-1)
References: 1. Schneider et al (1986). Eur.J.Pharmacol. 127 105.
2. Owens et al (1997). Biochem.J. 326 53.
3. Ohsawa et al (1998). Jpn.J.Pharmacol. 77 147.
Background: Rolipram is a racemic drug that increases brain cAMP availability by inhibiting phosphodiesterase. The S-(+)-Rolipram enantiomer is 2-10x less potent than the R-(-)-Rolipram compound. PDE4B is involved in dopamine-associated and stress-related behaviours, and is believed to be the PDE4 subtype involved in the antipsychotic effects of PDE4 inhibitors such as rolipram.
CAS Number: 85416-73-5
Description: S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 µM. It has anti-inflammatory and anti-depressant activity in the central nervous system.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: PDE4B
Biosafety Level: Not applicable (BSL-1)
References: 1. Schneider et al (1986). Eur.J.Pharmacol. 127 105.
2. Owens et al (1997). Biochem.J. 326 53.
3. Ohsawa et al (1998). Jpn.J.Pharmacol. 77 147.
| Artikelnummer | BPS27648-1 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 27648-1 |
| Green Labware | Nein |
| Verpackungseinheit | 10 mg |
| Mengeneinheit | STK |
| Produktinformation (PDF) |
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| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
