SCR130, CAS 2377858-38-1

Formulation: A crystalline solid

Formal Name: 2,4-bis(4-chlorophenyl)-8-thioxo-1,7,9-triazaspiro[4.5]dec-1-ene-6,10-dione

Purity: ≥98%

Formula Markup: C19H13Cl2N3O2S

Formula Weight: 418,3

Shelf life (days): 1460

CAS Number: 2377858-38-1

Notes: SCR130 is an inhibitor of non-homologous end joining (NHEJ) and a derivative of the DNA ligase IV inhibitor SCR7 (Item No. 18015).{49797} It selectively inhibits DNA ligase IV- over ligase I- or ligase III-mediated end-joining in cell-free assays when used at a concentration of 200 µM. SCR130 is cytotoxic to NALM6 and Reh leukemia and HeLa cervical cancer cells (IC50s = 2.2, 14.1, and 5.9 µM, respectively) and induces DNA double-strand breaks (DSBs) in Reh cells when used at concentrations ranging from 7 to 21 µM.

• Artikelnummer: CAY37779-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37779-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK