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Scriptaid , CAS 287383-59-9
Scriptaid , CAS 287383-59-9
Artikelnummer
BPS27200
Verpackungseinheit
1 mg
Hersteller
BPS Bioscience
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Biological Activity: Inhibits HDAC1 and HDAC3 with an IC50 value ~0.6 µM. Also inhibits HDAC8 with an IC50 ~ 1 µM.
CAS Number: 287383-59-9
Description: Scriptaid, also known as GCK 1026, is a histone deacetylase inhibitor with optimal concentration of 6-8 µM in a cell based assay. Scriptaid is exhibits lower toxicity than trichostatin A. Scriptaid inhibits tumor growth in vitro and in vivo. It also induces cell cycle arrest in colon cancer cells in culture.
Format: White to off-white crystalline solid
Purity: ≥98% by HPLC.
Solubility: Solubility in DMSO and DMF is 2.5 mg/ml. Sparingly soluble in aqueous buffers. Formaximum solubility, dissolve first in DMF and then dilute with aqueous buffer of choice.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Su, G.H., et al., Cancer Res. 2010; 60: 3137-3142.
2. Keen, J.C., et al., Cancer Res. Treat. 2003; 81: 177-186.
3. Lee, E.J., et al., Int. J. Oncol. 2008; 33: 767-776.
Biological Activity: Inhibits HDAC1 and HDAC3 with an IC50 value ~0.6 µM. Also inhibits HDAC8 with an IC50 ~ 1 µM.
CAS Number: 287383-59-9
Description: Scriptaid, also known as GCK 1026, is a histone deacetylase inhibitor with optimal concentration of 6-8 µM in a cell based assay. Scriptaid is exhibits lower toxicity than trichostatin A. Scriptaid inhibits tumor growth in vitro and in vivo. It also induces cell cycle arrest in colon cancer cells in culture.
Format: White to off-white crystalline solid
Purity: ≥98% by HPLC.
Solubility: Solubility in DMSO and DMF is 2.5 mg/ml. Sparingly soluble in aqueous buffers. Formaximum solubility, dissolve first in DMF and then dilute with aqueous buffer of choice.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Su, G.H., et al., Cancer Res. 2010; 60: 3137-3142.
2. Keen, J.C., et al., Cancer Res. Treat. 2003; 81: 177-186.
3. Lee, E.J., et al., Int. J. Oncol. 2008; 33: 767-776.
| Artikelnummer | BPS27200 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 27200 |
| Green Labware | Nein |
| Verpackungseinheit | 1 mg |
| Mengeneinheit | STK |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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Gernot Ensinger, M.Sc.
Laurent Haze
