Sirtinol, CAS 410536-97-9

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Background: Unlike TSA, Sirtinol does not inhibit class I and class II HDACs, indicating that it is a selective sirtuin inhibitor. The downregulation of SIRT1/2 expression plays an important role in the regulation of breast cancer apoptosis; thus, SIRT1/2 may be a novel molecular target for cancer therapy.

CAS Number: 410536-97-9

Description: Cell-permeable, selective sirtuin inhibitor that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.

Purity: ≥98% by HPLC

Solubility: DMSO 23 mg/ml, Water <1 mg/ml, Ethanol <1 mg/ml

Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Target: SIRT1, SIRT2

Biosafety Level: Not applicable (BSL-1)

References: 1. Wang J,et al. Int J Oncol. 2012 Sep;41(3):1101-9.
2. Grozinger CM, et al. J Biol Chem. 2001 Oct 19;276(42):38837-43.

• Artikelnummer: BPS27652-1
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27652-1
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK