SKLB23bb, CAS 1815580-06-3

Formulation: A solid

Formal Name: N-hydroxy-4-[2-methoxy-5-[methyl(2-methyl-4-quinazolinyl)amino]phenoxy]-butanamide

Purity: ≥98%

Formula Markup: C21H24N4O4

Formula Weight: 396,4

Shelf life (days): 1460

CAS Number: 1815580-06-3

Notes: SKLB23bb is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 17 nM).{49775} It is selective for HDAC6 over HDAC1-5 and HDAC7-11 (IC50s = 386->10,000 nM). SKLB23bb inhibits tubulin acetylation in HeLa cervical cancer cells (EC50 = 58.9 nM) and the proliferation of A375 melanoma and HeLa cells (IC50s = 45 and 49 nM, respectively). It also binds to the colchicine site in β-tubulin and inhibits microtubule formation in MDA-MB-231 cells.{49776} In vivo, SKLB23bb (12.5-50 mg/kg) reduces tumor growth in HCT116, A2780, and MCF-7 mouse xenograft models.

• Artikelnummer: CAY37242
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37242-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe