English
SP600125 , CAS 129-56-6
SP600125 , CAS 129-56-6
Artikelnummer
BPS27023
Verpackungseinheit
50 mg
Hersteller
BPS Bioscience
Verfügbarkeit:
wird geladen...
Preis wird geladen...
Products from BPS Bioscience require a minimum order value above 400€
CAS Number: 129-56-6
Description: Novel, potent and selective JNK-1,-2, and -3 inhibitor (Ki = 0.19 µM). SP600125 is an ATP-competitive reversible inhibitor with >20-fold selectivity vs. a range of kinases and enzymes tested. In cells, SP600125 caused a dose-dependent inhibition of the phosphorylation of c-Jun, the expression of inflammatory genes IL-2, COX-2, TNF-α, IFN-γ, and blocked the activation and differentiation of primary human CD4 cell cultures.
Format: Dark yellow solid
Purity: ≥99%
Solubility: Prepare initial stock solutions in DMSO (soluble at 65 mg/ml) for in vitro use; solubility in ethanol or water is low.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Bennett, B.L., et al. Proc. Natl. Acad. Sci. USA 98: 13681-13686 (2001).
2. Han, Z., et al. J. Clin. Invest. 108: 73-81 (2001).
CAS Number: 129-56-6
Description: Novel, potent and selective JNK-1,-2, and -3 inhibitor (Ki = 0.19 µM). SP600125 is an ATP-competitive reversible inhibitor with >20-fold selectivity vs. a range of kinases and enzymes tested. In cells, SP600125 caused a dose-dependent inhibition of the phosphorylation of c-Jun, the expression of inflammatory genes IL-2, COX-2, TNF-α, IFN-γ, and blocked the activation and differentiation of primary human CD4 cell cultures.
Format: Dark yellow solid
Purity: ≥99%
Solubility: Prepare initial stock solutions in DMSO (soluble at 65 mg/ml) for in vitro use; solubility in ethanol or water is low.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Bennett, B.L., et al. Proc. Natl. Acad. Sci. USA 98: 13681-13686 (2001).
2. Han, Z., et al. J. Clin. Invest. 108: 73-81 (2001).
| Artikelnummer | BPS27023 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 27023 |
| Green Labware | Nein |
| Verpackungseinheit | 50 mg |
| Mengeneinheit | STK |
| Produktinformation (PDF) |
|
| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
