STM2457, CAS 2499663-01-1

Formulation: A solid

Formal Name: N-[[6-[[(cyclohexylmethyl)amino]methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide

Purity: ≥98%

Formula Markup: C25H28N6O2

Formula Weight: 444,5

Shelf life (days): 1460

CAS Number: 2499663-01-1

Notes: STM2457 is an inhibitor of the methyltransferase-like 3 (METTL3) and METTL14 complex (IC50 = 16.9 µM).{59966} It inhibits growth in a panel of acute myeloid leukemia (AML) cell lines (IC50s = 0.6-10.3 µM). STM2457 also inhibits the proliferation, migration, and invasion of HuCC-T1 and HCCC-9810 intrahepatic cholangiocarcinoma (ICC) cells in a concentration-dependent manner.{69159} It increases survival in a patient-derived xenograft (PDX) mouse model of AML when administered at a dose of 50 mg/kg.{59966}

• Artikelnummer: CAY34280-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34280-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe