TAK-285, CAS 871026-44-7

Formulation: A solid

Formal Name: N-[2-[4-[[3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl]amino]-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-3-hydroxy-3-methyl-butanamide

Purity: ≥95%

Formula Markup: C26H25ClF3N5O3

Formula Weight: 548

Shelf life (days): 1460

CAS Number: 871026-44-7

Notes: TAK-285 is a dual inhibitor of EGFR and HER2 (IC50s = 23 and 17 nM, respectively).{61699} It is selective for EGFR and HER2 over a panel of 36 kinases (IC50s = 250->10,000 nM). TAK-285 inhibits the proliferation of BT474 breast cancer cells (GI50 = 17 nM) as well as induces tumor regression in a 4-1st gastric adenocarcinoma rat xenograft model when administered at doses of 25 and 50 mg/kg.

• Artikelnummer: CAY29157-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29157-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe