Tenovin-6 , CAS 1011557-82-6

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Biological Activity: Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 of 21 µM, 10 µM, and 67 µM, respectively.

CAS Number: 1011557-82-6

Description: Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 and SIRT2 inhibitor as well as an activator of the p53 pathway. Studies show that Tenovin-6 increases p53 levels more than Tenovin-1 and is also more toxic to yeast. Tenovin-6 has also been shown to inhibit SIRT3.

Purity: ≥98% by HPLC

Solubility: Soluble in DMSO

Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Target: SIRTs 1-3

Biosafety Level: Not applicable (BSL-1)

References: McCarthy, A.R, et al. Bioorg Med Chem. 2012 Mar 1;20(5):1779-93.

• Artikelnummer: BPS27661-3
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27661-3
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK