TFC 007, CAS 927878-49-7

Formulation: A crystalline solid

Formal Name: N-[4-[4-(4-morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide

Purity: ≥98%

Formula Markup: C27H29N5O4

Formula Weight: 487,6

Shelf life (days): 730

CAS Number: 927878-49-7

Notes: TFC 007 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50 = 0.083 µM).{20048} It is selective for H-PGDS over lipocalin PGDS (L-PGDS) and microsomal PGE2 synthase (mPGES) at 100 µM. It is also selective for H-PGDS over COX-1, COX-2, 5-lipoxygenase (5-LO), leukotriene C4 (LTC4) synthase, and thromboxane (TX) synthase, as well as the histamine H1 and cysteinyl leukotriene 1 (CysLT1) receptors, at 10 µM. TFC 007 (30 mg/kg) inhibits antigen-induced increases in the production of PGD2 (Item No. 12010) in nasal cavity lavage fluid and reduces nasal blockage in a guinea pig model of allergic rhinitis.

• Artikelnummer: CAY17971-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 17971-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe