ThioLox, CAS 1202193-89-2

Formulation: A solid

Formal Name: 2-amino-N-butyl-5-phenyl-3-thiophenecarboxamide

Purity: ≥98%

Formula Markup: C15H18N2OS

Formula Weight: 274,4

Shelf life (days): 1460

CAS Number: 1202193-89-2

Notes: ThioLox is an inhibitor of 15-lipoxygenase 1 (15-LO-1; Ki = 3.3 µM).{65796} It also is an inhibitor of P. falciparum aspartate carbamoyltransferase (IC50 = 3.32 µM).{65797} ThioLox (50 µM) reduces LPS-induced expression of the mRNAs encoding TNF-α, inducible nitric oxide synthase (iNos), Il-1β, Il-6, Il-8, and Il-12b in mouse lung slices.{65796} It inhibits increases in lipid peroxidation and mitochondrial superoxide formation, as well as cell death, induced by the excitatory neurotransmitter glutamate (L-glutamic acid; Item No. 30377) in mouse HT22 hippocampal cells when used at a concentration of 10 µM.

• Artikelnummer: CAY38946-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38946-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK