Triptolide, CAS 38748-32-2

Formulation: A crystalline solid

Formal Name: 3bS,4,4aS,6R,6aR,7aS,7bS,8bS,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-trisoxireno[4b,5aS:6,7:8aS,9]phenanthro[1,2-c]furan-1(3H)-one

Purity: ≥98%

Formula Markup: C20H24O6

Formula Weight: 360,4

Shelf life (days): 730

CAS Number: 38748-32-2

Notes: Triptolide is a diterpenoid triepoxide that has been found in T. wilfordii and has diverse biological activities.{22058,57803,57804,57805} It inhibits dCTP pyrophosphatase 1 (Ki = 168 µM), an enzyme that prevents halogenated nucleotides from entering DNA synthesis.{22058} It reduces viability of A549, H1299, NCI H520, NCI H1650, and H1975 human non-small cell lung cancer (NSCLC) cells when used at a concentration of 50 nM.{57803} Intranasal administration of liposomes containing triptolide (0.4 mg/kg) reduces tumor growth in a rat orthotopic model of lung cancer. Triptolide (0.2 mg/kg) reduces intestinal inflammation and prevents colon shortening in a mouse model of colitis induced by dextran sulfate (Item No. 23250).{57804} It also inhibits skin allograft rejection and increases graft survival time in mice when administered at a dose of 0.1 mg/kg per day post-transplantation.{57805}

• Artikelnummer: CAY11973-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11973-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe