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Tubastatin A hydrochloride , CAS 1310693-92-5
Tubastatin A hydrochloride , CAS 1310693-92-5
Artikelnummer
BPS27108
Verpackungseinheit
10 mg
Hersteller
BPS Bioscience
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Biological Activity: Inhibits HDAC6 with IC50 = 15 nM and HDAC1 with IC50 = 16.4 µM.
CAS Number: 1310693-92-5
Description: Tubastatin A is a potent HDAC6 inhibitor. It demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50 >16 µM), excluding HDAC8 (IC50 = 0.9 µM). Tubastatin A induces a-tubulin hyperacetylation at 2.5 µM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, it displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 µM.
Format: White to off-white crystalline solid; granular or powder.
Purity: ≥98% by HPLC.
Solubility: Solubility in DMSO is 8 mg/ml, and in water and ethanol is < 1 mg/ml.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: Butler, K.V., et al. J Am Chem Soc. 2010; 132(31): 10842-6.
Biological Activity: Inhibits HDAC6 with IC50 = 15 nM and HDAC1 with IC50 = 16.4 µM.
CAS Number: 1310693-92-5
Description: Tubastatin A is a potent HDAC6 inhibitor. It demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50 >16 µM), excluding HDAC8 (IC50 = 0.9 µM). Tubastatin A induces a-tubulin hyperacetylation at 2.5 µM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, it displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 µM.
Format: White to off-white crystalline solid; granular or powder.
Purity: ≥98% by HPLC.
Solubility: Solubility in DMSO is 8 mg/ml, and in water and ethanol is < 1 mg/ml.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: Butler, K.V., et al. J Am Chem Soc. 2010; 132(31): 10842-6.
| Artikelnummer | BPS27108 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 27108 |
| Green Labware | Nein |
| Verpackungseinheit | 10 mg |
| Mengeneinheit | STK |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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Gernot Ensinger, M.Sc.
Laurent Haze
