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U0126 , CAS 109511-58-2
U0126 , CAS 109511-58-2
Artikelnummer
BPS27012
Verpackungseinheit
25 mg
Hersteller
BPS Bioscience
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Biological Activity: U0126 antagonizes AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase MEK with IC50 of 0.07 µM for MEK1 and 0.06 µM for MEK2.
CAS Number: 109511-58-2
Description: U0126 is a selective inhibitor of mitogen-activated protein kinase kinases, MEK-1 and MEK-2. It is a weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.
Format: White to off-white crystalline solid; granular or powder.
Purity: ≥99% by HPLC
Solubility: Soluble in DMSO at 200 mg/ml. It is poorly soluble in ethanol and water.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Favata, M.R., et al., J. Biol. Chem. 1998; 273: 18623 - 18632.
2. DeSilva, D.R., et al., J. Immunol. 1998; 160: 4175 - 4181.
3. Scherle, P.A., et al., J. Immunol. 1998; 161: 5681 - 5686.
Biological Activity: U0126 antagonizes AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase MEK with IC50 of 0.07 µM for MEK1 and 0.06 µM for MEK2.
CAS Number: 109511-58-2
Description: U0126 is a selective inhibitor of mitogen-activated protein kinase kinases, MEK-1 and MEK-2. It is a weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.
Format: White to off-white crystalline solid; granular or powder.
Purity: ≥99% by HPLC
Solubility: Soluble in DMSO at 200 mg/ml. It is poorly soluble in ethanol and water.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Favata, M.R., et al., J. Biol. Chem. 1998; 273: 18623 - 18632.
2. DeSilva, D.R., et al., J. Immunol. 1998; 160: 4175 - 4181.
3. Scherle, P.A., et al., J. Immunol. 1998; 161: 5681 - 5686.
| Artikelnummer | BPS27012 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 27012 |
| Green Labware | Nein |
| Verpackungseinheit | 25 mg |
| Mengeneinheit | STK |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
