UCB 9260, CAS 1515888-53-5

Formulation: A solid

Formal Name: 1-[(2,5-dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-α-4-pyridinyl-1H-benzimidazole-2-methanol

Purity: ≥95%

Formula Markup: C26H25N5O

Formula Weight: 423,5

Shelf life (days): 1460

CAS Number: 1515888-53-5

Notes: UCB 9260 is a TNF inhibitor.{66480} It binds to trimeric TNF (Kd = 13.8 nM) and selectively increases the thermal stability of the TNF trimer over 10 other TNF superfamily members at 100 µM. UCB 9260 inhibits TNF-induced NF-κB activity in a reporter assay using HEK293 cells and TNF-induced cytotoxicity in L-929 fibroblasts (IC50s = 202 and 116 nM, respectively). In vivo, UCB 9260 (30-300 mg/kg, p.o.) reduces TNF-induced peritoneal neutrophil recruitment in mice. Intraperitoneal administration of UCB 9260 (150 mg/kg) decreases disease severity in a mouse model of collagen antibody-induced arthritis.

• Artikelnummer: CAY37336-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37336-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK