Valproic Acid, CAS 99-66-1

Formulation: A neat liquid

Formal Name: 2-propyl-pentanoic acid

Purity: ≥95%

Formula Markup: C8H16O2

Formula Weight: 144,2

Shelf life (days): 730

CAS Number: 99-66-1

Notes: Valproic acid is an analog of the natural fatty acid valeric acid that inhibits class I histone deacetylases (HDACs) with IC50 values of approximately 2 mM.{17456} It decreases the number of axon branches in sensory neurons isolated from newborn rat dorsal root ganglia, an effect that is reversed by inositol-1,4,5-trisphosphate (1,4,5-IP3).{9786} In vivo, valproic acid inhibits amyloid-β deposition and neuritic plaque formation and decreases escape latency in Morris water maze, indicating improved memory performance, in the APP23 transgenic mouse model of Alzheimer's disease.{17458} Valproic acid has anticonvulsant activity in the pentylenetetrazole seizure threshold test in mice (ED50 = 0.71 mmol/kg) but induces neurotoxicity when administered at doses greater than or equal to 1.2 mmol/kg.{42211} Formulations containing valproic acid have been used in the treatment of bipolar disorder and various seizure disorders.

• Artikelnummer: CAY35739-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35739-250
• Green Labware: Nein
• Verpackungseinheit: 250 g
• Mengeneinheit: STK
• Methode: Reinstoffe