Y-33075 (hydrochloride), CAS 471843-75-1

Formulation: A solid

Formal Name: 4-[(1R)-1-aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl-benzamide, monohydrochloride

Purity: ≥98%

Formula Markup: C16H16N4O • HCl

Formula Weight: 316,8

Shelf life (days): 1460

CAS Number: 471843-75-1

Notes: Y-33075 is an inhibitor of Rho-associated kinase 2 (ROCK2; IC50 = 3.6 nM).{62542} It is selective for ROCK2 over PKC and calcium/calmodulin-dependent protein kinase II (CaMKII; IC50s = 420 and 810 nM, respectively). Topical application of Y-33075 (0.05% v/v) reduces intraocular pressure in rabbit and cynomolgus monkeys. Y-33075 (10 and 100 µM) increases axonal regeneration at the crush site in a cat model of surgically-induced optic nerve damage.{62543} It also inhibits demyelination and reduces the incidence of relapse episodes in a mouse model of chronic relapsing experimental autoimmune encephalomyelitis (EAE).{62544}

• Artikelnummer: CAY36216-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36216-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe