YM-155 (chloride), CAS 355406-09-6

Formulation: A solid

Formal Name: 4,9-dihydro-3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium, monochloride

Purity: ≥98%

Formula Markup: C20H19N4O3 • Cl

Formula Weight: 398,8

Shelf life (days): 1460

CAS Number: 355406-09-6

Notes: YM-155 is a survivin inhibitor.{22212} It inhibits survivin promoter activity in a reporter assay (IC50 = 0.54 nM). YM-155 (10-1,000 nM) reduces survivin levels and induces apoptosis in PC3 and PPC-1 prostate cancer cells. In vivo, YM-155 (3 and 10 mg/kg) inhibits tumor growth, decreases intratumor survivin levels, and induces tumor regression in a PC3 mouse xenograft model. It reduces tumor volume in a MiaPaCa-2 pancreatic cancer mouse xenograft model.{22211} YM-155 also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) papain-like protease (PLpro; IC50 = 2.47 µM) and reduces the number of viral RNA copies in SARS-CoV-2-infected Vero E6 cells.{64583}

• Artikelnummer: CAY36827-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36827-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe