Z-VEID-FMK

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Amino Acid Sequence: Z-Val-Glu(OMe)-Ile-Asp(OMe)-CH2F

Background: VEID is the specific recognition sequence for caspase-6/Mch2. Caspase 6 is only one of at least three effector caspases, the others being caspase 3 and 7, that are active during caspasedependent apoptosisLoss of DNA-binding activity and TNFα-induced apoptosis can be prevented by Z-VEID-FMK. The caspase-6-speci?c inhibitor Z-VEID-FMK signi?cantly prevented apoptosis of caspase-6-microinjected neurons, and was also able to abolish the cleavage of procaspase-8, although caspase-6 is activated downstream of caspase-8 in Fas-mediated apoptosis.

Biological Activity: We recommend using 2-10 µM for inhibiting caspase activity in cell culture. The optimal dose may vary for different cells and culture conditions.

Description: Z-VEID-FMK is a synthetic peptide that irreversibly inhibits activity of VEID-dependent caspases (e.g., caspase-6). The inhibitor is designed as a methyl ester to facilitate cell permeability. Can be used for both in vitro and in vivo studies--see note for using this product in vitro.

Purity: ≥90% by HPLC

Solubility: Soluble in DMSO (20 mM)

Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Target: Caspase 6

Biosafety Level: Not applicable (BSL-1)

• Artikelnummer: BPS27669-2
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27669-2
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK