ZZW-115, CAS 10122-45-9

ZZW-115, CAS 10122-45-9
Artikelnummer
CAY34974-1
Verpackungseinheit
1 mg
Hersteller
Cayman Chemical

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Formulation: A solid

Formal Name: N,N-dimethyl-4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanamine, trihydrochloride

Purity: ≥95%

Formula Markup: C24H31F3N4S • 3HCl

Formula Weight: 574

Shelf life (days): 1460

CAS Number: 10122-45-9

Notes: ZZW-115 is an inhibitor of nuclear protein 1 (NUPR1).{65137} It binds to NUPR1 (Kd = 2.1 µM) in a cell-free assay. ZZW-115 is cytotoxic against a panel of 11 pancreatic ductal adenocarcinoma cell lines (IC50s = 0.84-4.93 µM), as well as against a panel of 16 additional cancer cell lines, including glioblastoma, lymphoma, and leukemia cells (IC50s =0.25-7.75 µM). It induces apoptosis and necrosis in MiaPaCa-2, LIPC, Foie8b, 02-063, and HN14 pancreatic cancer cells when used at concentrations of 3 and 5 µM. ZZW-115 induces accumulation of reactive oxygen species (ROS), lipid peroxidation, and ferroptosis in MiaPaCa-2 cells in a concentration-dependent manner.{63308} It reduces tumor growth in a MiaPaCa-2 mouse xenograft model when administered at doses of 1, 2.5, or 5 mg/kg.{65137}
Mehr Informationen
Artikelnummer CAY34974-1
Hersteller Cayman Chemical
Hersteller Artikelnummer 34974-1
Green Labware Nein
Verpackungseinheit 1 mg
Mengeneinheit STK
Methode Reinstoffe
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