Formulation: A solid
Formal Name: N-methyl-8-[(1S)-1-methyl-2-[(2′-methyl[4,5′-bipyrimidin]-6-yl-4′,6′-d2)amino]ethyl]-4-quinolinecarboxamide
Purity: ≥95%
Formula Markup: C23H21D2N7O
Formula Weight: 415,5
Shelf life (days): 1460
CAS Number: 1476074-39-1
Notes: VX-984 is an inhibitor of DNA protein kinase (DNA-PK).{51927} It inhibits radiation-induced increases in phosphorylated DNA-PK levels in U251 and NSC11 glioblastoma cells when used at concentrations of 250 or 500 nM. VX-984 (1 µM) induces mutagenic NHEJ and homologous recombination DNA repair pathways in a reporter assay using U2OS cells.{51928} It potentiates radiation-induced cytotoxicity and DNA damage in U251 and NSC11 cells when used at concentrations of 250 or 500 nM.{51927} In vivo, VX-984 (50 mg/kg twice per day), in combination with radiation, increases survival in a U251 orthotopic mouse xenograft model.
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