Product Description: 1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1].
Applications: Cancer-programmed cell death
Formula: C6H12I2O2
References: [1]Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.
CAS Number: 36839-55-1
Molecular Weight: 369.97
Compound Purity: 98.66
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: PROTAC Linkers