Product Description: 103D5R (Compound 15) is an inhibitor for the activation of hypoxia-inducible factor-1 (HIF-1) with an IC50 of 35 µM, through reduction of the HIF-1α protein synthesis. 103D5R inhibits the proliferation of LN229 with IC50 of 26 µM[1].
Applications: Cancer-programmed cell death
Formula: C20H21N3O2
References: [1]Nagle DG, et al., Natural product-based inhibitors of hypoxia-inducible factor-1 (HIF-1). Curr Drug Targets. 2006 Mar;7(3):355-69.