12(R)-HETE, CAS 82337-46-0

Product Description: 12(R)-HETE is a metabolite of Arachidonic acid, AA (HY-109590) and can be found in skin from psoriatic lesions. 12(R)-HETE induces lymphocytes chemotaxis, stimulates calcium mobilization and chemotaxis in neutrophils via the BLT1 receptor, activates the aryl hydrocarbon receptor, and inhibits Na+/K+ ATPase activity in the corneal epithelium[1][2][3][4].

Applications: COVID-19-immunoregulation

Formula: C20H32O3

References: [1]Bacon KB, et al., Contrasting in vitro lymphocyte chemotactic activity of the hydroxyl enantiomers of 12-hydroxy-5,8,10,14-eicosatetraenoic acid. Br J Pharmacol. 1988 Nov;95(3):966-74./[2]Powell WS, et al., Effects of oxo and dihydro metabolites of 12-hydroxy-5,8,10,14-eicosatetraenoic acid on chemotaxis and cytosolic calcium levels in human neutrophils. J Leukoc Biol. 1995 Feb;57(2):257-63./[3]Chiaro CR, et al., 12(R)-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid [12(R)-HETE], an arachidonic acid derivative, is an activator of the aryl hydrocarbon receptor. Mol Pharmacol. 2008 Dec;74(6):1649-56./[4]Schwartzman ML, et al., 12(R)-hydroxyicosatetraenoic acid: a cytochrome-P450-dependent arachidonate metabolite that inhibits Na+,K+-ATPase in the cornea. Proc Natl Acad Sci U S A. 1987 Nov;84(22):8125-9.

CAS Number: 82337-46-0

Molecular Weight: 320.47

Compound Purity: 99.90

Research Area: Inflammation/Immunology; Others

Solubility: 10 mM in DMSO

Target: Aryl Hydrocarbon Receptor;Na+/K+ ATPase

• Artikelnummer: MEXHY-124404-50UG
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-124404-50UG
• Green Labware: Nein
• Verpackungseinheit: 50 μg（312.04 μM * 500 μL in Ethanol）
• Mengeneinheit: STK