5-Hydroxymethylcytosine, CAS 1123-95-1

Product Description: 5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development[1].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C5H7N3O2

References: [1]Gerd P Pfeifer, et al. 5-hydroxymethylcytosine and its potential roles in development and cancer. Epigenetics Chromatin. 2013 May 1;6(1):10. /[2]Xiao-Long Cui, et al. A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation. Nat Commun. 2020 Dec 2;11(1):6161.

CAS Number: 1123-95-1

Molecular Weight: 141.13

Compound Purity: 99.91

Research Area: Cancer; Metabolic Disease

Target: Endogenous Metabolite

• Artikelnummer: MEXHY-W018324-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-W018324-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK