Product Description: 5-Octyl-α-ketoglutarate (5-Octyl 2-oxopentanedioate) is a cell-permeable substrate for lysine demethylase. 5-Octyl-α-ketoglutarate is related to protein demethylation, inhibits cell proliferation of wtCRBN expressing cells, and also enhances Lenalidomide (HY-A0003)-induced sensitivity and inhibits myeloma (MM) ) drug resistance of cells. When myeloma (MM) cells undergo glutamine-dependent proliferation, α-ketoglutarate increases glutamine catabolism to promote protein demethylation[1].
Formula: C13H22O5
References: [1]Chirackal S, et al. Myeloma Cells Addicted to Glutamine for Biomass Production Are Sensitive to Lenalidomide[J]. Blood, 2019, 134: 4410.
CAS Number: 1616344-00-3
Molecular Weight: 258.31
Research Area: cancer
Solubility: 10 mM in DMSO
Target: Others