6-Thioguanine (Standard), CAS 154-42-7

Product Description: 6-Thioguanine (Standard) is the analytical standard of 6-Thioguanine. This product is intended for research and analytical applications. 6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

Formula: N/A

References: [1]Chuang SJ, et al. 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. Sci Rep. 2018 Feb 15;8(1):3102./[2]Wang H, et al. 6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Biochemistry. 2009 Mar 17;48(10):2290-9./[3]LaDuke KE, et al. Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes. Am J Vet Res. 2015 Jul;76(7):649-55.

CAS Number: 154-42-7

Molecular Weight: N/A

Research Area: Cancer; Infection; Inflammation/Immunology

Target: Apoptosis;Autophagy;Deubiquitinase;DNA Methyltransferase;Endogenous Metabolite;SARS-CoV

• Artikelnummer: MEXHY-13765R-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-13765R-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK