9-Decyn-1-ol, CAS 17643-36-6

Product Description: 9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively[1]. 9-Decyn-1-ol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Applications: Cancer-programmed cell death

Formula: C10H18O

References: [1] You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7.

CAS Number: 17643-36-6

Molecular Weight: 154.25

Compound Purity: 99.69

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: PROTAC Linkers

• Artikelnummer: MEXHY-130985-10G
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-130985-10G
• Green Labware: Nein
• Verpackungseinheit: 10 g
• Mengeneinheit: STK