A947, CAS 2378056-80-3

Product Description: A947 is a potent and selective SMARCA2 proteolysis-targeting chimera molecule (PROTAC). A947 also is a potent and moderately selective SMARCA2 degrader. A947 has binding affinity to the SMARCA2 bromodomain with a Kd value of 93 nM. A947 can be used for the research of cancer[1].

Applications: Cancer-programmed cell death

Formula: C61H76N12O7S

References: [1] Jennifer Cantley, et al. Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers. Nat Commun. 2022 Nov 10;13(1):6814.

CAS Number: 2378056-80-3

Molecular Weight: 1121.40

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;Epigenetic Reader Domain;PROTACs

• Artikelnummer: MEXHY-148381-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-148381-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK