AChE-IN-63, CAS 876685-78-8

Product Description: AChE-IN-63 (Compound 5AD) is a selective inhibitor of hAChE (IC50=0.103 μM). AChE-IN-63 also inhibits hBChE and hBACE-1 (IC50= 10 μM (hBChE); 1.342 μM (hBACE-1)). AChE-IN-63 inhibits Aβ aggregation, preventing the formation and deposition of Aβ1-42. AChE-IN-63 can effectively penetrate the blood-brain barrier and is orally effective. It is primarily used in Alzheimer's disease research[1].

Formula: C18H19N5O

References: [1]Singh A, et al. Structure-Guided Design, Synthesis, and Biological Evaluation of Peripheral Anionic Site Selective and Brain Permeable Novel Oxadiazole-Piperazine Conjugates against Alzheimer's Disease with Antioxidant Potential. ACS Omega. 2024 Apr 11;9(16):18169-18182.

CAS Number: 876685-78-8

Molecular Weight: 321.38

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: Amyloid-β;Beta-secretase;Cholinesterase (ChE)

• Artikelnummer: MEXHY-158261-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-158261-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK