AGI-14100, CAS 1448346-43-7

Product Description: AGI-14100 is a metabolically stable and orally available mIDH1 inhibitor (IC50=6 nM). The pharmacochemical optimization of AGI-14100 is aimed at eliminating hPXR activation, resulting in the final drug candidate AG-120. AG-120 can be used in the study of cancers carrying IDH1 mutations. The discovery and development of AGI-14100 can be used for further studies of mutant isocitrate dehydrogenase 1 (mIDH1) inhibitors[1].

Formula: C29H22ClF4N5O3

References: [1]Popovici-Muller J, et al. Discovery of AG-120 (Ivosidenib): a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers[J]. ACS medicinal chemistry letters, 2018, 9(4): 300-305.

CAS Number: 1448346-43-7

Molecular Weight: 599.96

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Isocitrate Dehydrogenase (IDH)

• Artikelnummer: MEXHY-120181-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-120181-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK