Product Description: Aldose reductase-IN-7 (Compound 6k) targets Aldose reductase. Aldose reductase-IN-7 exhibits potent enzyme inhibitory activity (Ki = 0.186 ± 0.020 μM), showing superiority to Epalrestat (HY-66009), which is currently in clinical use. Aldose reductase-IN-7 is less cytotoxic and possesses potent anticancer activity[1].
Formula: C21H20N4O7
References: [1]Güleç Ö, et al. Novel spiroindoline derivatives targeting aldose reductase against diabetic complications: Bioactivity, cytotoxicity, and molecular modeling studies. Bioorg Chem. 2024 Apr;145:107221.
Molecular Weight: 440.41
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Aldose Reductase