Amifostine (trihydrate) (Standard), CAS 112901-68-5

Product Description: Amifostine (trihydrate) (Standard) is the analytical standard of Amifostine (trihydrate). This product is intended for research and analytical applications. Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action[1][2][3][4].

Formula: N/A

References: [1]D Maurici, et al. Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene. 2001 Jun 14;20(27):3533-40./[2]Efstathia Giannopoulou, et al. Amifostine inhibits angiogenesis in vivo. J Pharmacol Exp Ther. 2003 Feb;304(2):729-37./[3]Michael I Koukourakis, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004 Jan;53(1):8-14./[4]John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47./[5]Shao-Ze Wu, et al. Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress. Oxid Med Cell Longev. 2017;2017:4130824.

CAS Number: 112901-68-5

Molecular Weight: N/A

Research Area: Cancer

Target: HIF/HIF Prolyl-Hydroxylase;MDM-2/p53

• Artikelnummer: MEXHY-B0639AR-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0639AR-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK