Anti-inflammatory agent 79

Product Description: Anti-inflammatory agent 79 (compound 17q) is an isoquinolinone derivative-based HIF-1 inhibitor (IC50: 0.55 μM), which can effectively block HIF-1 signals and increase HIF- Degradation of 1α. Anti-inflammatory agent 79 inhibits synovial invasion and migration and inhibits angiogenesis. Anti-inflammatory agent 79 also effectively reduced foot swelling and arthritis in a mouse inflammation model, and down-regulated the levels of inflammatory factors and blood vessel proliferation in the body.[13][1].

Formula: C21H17NO2

References: [1]Cai L, et al. Discovery of novel diaryl substituted isoquinolin-1(2H)-one derivatives as hypoxia-inducible factor-1 signaling inhibitors for the treatment of rheumatoid arthritis. Eur J Med Chem. 2024 Apr 16;271:116417.

Molecular Weight: 315.37

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: HIF/HIF Prolyl-Hydroxylase

• Artikelnummer: MEXHY-163512-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-163512-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK