Antifolate C2, CAS 1286279-90-0

Antifolate C2, CAS 1286279-90-0
Artikelnummer
MEXHY-126830-0
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MedChemExpress

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Product Description: Antifolate C2 is an anti-folate compound that has inhibitory effects on the proliferation of non-squamous non-small cell lung cancer (NS-NSCLC). Antifolate C2 achieves tumor selectivity by targeting proton-coupled folate transporter (PCFT), which is more selective to PCFT than the commonly used anti-folate drug Pemetrexed (HY-10820). Antifolate C2 blocks the biosynthesis of deoxypurine nucleotides by inhibiting glycinamide ribonucleotide formyltransferase (GARFTase), ultimately inhibiting the proliferation of tumor cells. Antifolate C2 can be used in studies of NS-NSCLC, especially in patients who do not respond well to Pemetrexed[1].

Formula: C19H21N5O6S

References: [1]Wilson M R, et al. Targeting nonsquamous nonsmall cell lung cancer via the proton-coupled folate transporter with 6-substituted pyrrolo [2, 3-d] pyrimidine thienoyl antifolates[J]. Molecular pharmacology, 2016, 89(4): 425-434.

CAS Number: 1286279-90-0

Molecular Weight: 447.46

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Antifolate;Apoptosis
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Artikelnummer MEXHY-126830-0
Hersteller MedChemExpress
Hersteller Artikelnummer HY-126830-0
Green Labware Nein
Verpackungseinheit Get quote
Mengeneinheit STK
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