AZD-5438, CAS 602306-29-6

Product Description: AZD-5438 is a potent CDK1, CDK2, and CDK9 inhibitor, with IC50s of 16 nM, 6 nM, and 20 nM in cell-free assays, respectively. AZD-5438 shows less inhibition activity against GSK3β, CDK5 and CDK6[1].

Applications: Cancer-Kinase/protease

Formula: C18H21N5O2S

References: [1]Byth KF, et al. AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol Cancer Ther. 2009 Jul;8(7):1856-66. Epub 2009 Jun 9./[2]Raghavan P, et al. AZD5438, an Inhibitor of Cdk1, 2, and 9, Enhances the Radiosensitivity of Non-Small Cell Lung Carcinoma Cells. Int J Radiat Oncol Biol Phys. 2012 Jul 12.

CAS Number: 602306-29-6

Molecular Weight: 371.46

Compound Purity: 99.85

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: CDK

• Artikelnummer: MEXHY-10012-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-10012-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK