AZD7545, CAS 252017-04-2

Product Description: AZD7545 is a potent, competitive, selective PDHK2 (pyruvate dehydrogenase kinase 2) inhibitor with IC50s of 36.8 nM, 6.4 nM for PDHK1 and PDHK2, respectively[1].

Applications: Metabolism-sugar/lipid metabolism

Formula: C19H18ClF3N2O5S

References: [1]Morrell JA, et al. AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2. Biochem Soc Trans. 2003 Dec;31(Pt 6):1168-70./[2]Cesi G et al. ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells. Mol Cancer. 2017 Jun 8;16(1):102./[3]Mayers RM, et al. AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats. Biochem Soc Trans. 2003 Dec;31(Pt 6):1165-7.

CAS Number: 252017-04-2

Molecular Weight: 478.87

Compound Purity: 99.81

Research Area: Metabolic Disease

Solubility: DMSO : ≥ 46 mg/mL

Target: PDHK

• Artikelnummer: MEXHY-16082-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-16082-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK