Product Description: BCL-xL/BCL-2 ligand 1 (compound 72-1) is a BCL-xL and BCL-2 protein ligand. BCL-xL/BCL-2 ligand 1 can be connected to the E3 ligase by a linker to form PROTACs (HY-161410)[1][2].
Formula: C48H53ClF3N5O7S3
References: [1]Guangrong Zheng, et al. Bcl-xl/bcl-2 dual degraders for treatment of cancers. WO2023107606A1./[2]Nayak D, et al. Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun. 2024 Mar 29;15(1):2743.