Bexarotene (Standard), CAS 153559-49-0

Product Description: Bexarotene (Standard) is the analytical standard of Bexarotene. This product is intended for research and analytical applications. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM)[1][2][3]. Bexarotene can be used for the research of cutaneous T-cell lymphoma.

Formula: N/A

References: [1]Nathalia Rodrigues de Almeida, et al.  A review of the molecular design and biological activities of RXR agonists. Med Res Rev. 2019 Jul;39(4):1372-1397./[2]Danyang Shen, et al. Synergistic effect of a retinoid X receptor-selective ligand bexarotene and docetaxel in prostate cancer. Onco Targets Ther. 2019 Sep 24;12:7877-7886./[3]Y Wang, et al. Prevention of lung cancer progression by bexarotene in mouse models. Oncogene. 2006 Mar 2;25(9):1320-9.

CAS Number: 153559-49-0

Molecular Weight: N/A

Research Area: Cancer

Target: Autophagy;RAR/RXR

• Artikelnummer: MEXHY-14171R-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-14171R-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK