BIO-8169, CAS 2792153-06-9

Product Description: BIO-8169 is a selective inhibitor for interleukin receptor-associated kinase 4 (IRAK 4), with an IC50 of 0.23 nM. BIO-8169 exhibits good pharmacokinetic character, reduces the production of pro-inflammatory cytokines, and attenuates the autoimmune encephalomyelitis in EAE mice model. BIO-8169 exhibits good blood brain penetrant with a rat Kpu,u of 0.7[1].

Formula: C24H27N5O4

References: [1]Pfaffenbach M, et al., Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation. J Med Chem. 2024 May 23;67(10):8383-8395.

CAS Number: 2792153-06-9

Molecular Weight: 449.50

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: IRAK

• Artikelnummer: MEXHY-158374-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-158374-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK