Product Description: BIT-225 is an inhibitor for Vpu protein through block of Vpu ion channel, and thus inhibits the release of HIV-1, especially in monocyte-derived macrophages (EC50 is 2.25 μM), without significant cytotoxicity (TC50 is 284 μM)[1].
Formula: C16H15N5O
References: [1]Khoury G, et al., Antiviral efficacy of the novel compound BIT225 against HIV-1 release from human macrophages. Antimicrob Agents Chemother. 2010 Feb;54(2):835-45.
CAS Number: 917909-71-8
Molecular Weight: 293.32
Research Area: Infection
Target: HIV