BMS-394136, CAS 343246-73-1

Product Description: BMS-394136 (compound 1) is a potent inhibitor of Kv 1.5, with an IC50 of 0.05 μM. BMS-394136 is a selective IKur inhibitor. BMS-394136 dose-dependently prolongs atrial effective refractory period (AERP) and action potential duration (APD) without effecting ventricular effective refractory period (VERP). BMS-394136 can be used for acute atrial ischemia research[1].

Applications: Neuroscience-Neuromodulation

Formula: C24H21Cl2FN4O

References: [1]Gunaga P, et al. Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide. J Med Chem. 2017 May 11;60(9):3795-3803./[2]Dezhi Xing, et al. Abstract 12964: Acute Atrial Ischemia Increases the Activity of BMS-394136, a Selective IKur Inhibitor, on Atrial Refractoriness and APD. Originally published 23 Mar 2018. Circulation. 2010;122:A12964.

CAS Number: 343246-73-1

Molecular Weight: 471.35

Research Area: Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Potassium Channel

• Artikelnummer: MEXHY-107036-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-107036-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK