Product Description: BMS-932481 is an orally active modulator for γ-secretase, selectively reduce Aβ1-42 and Aβ1-40 production, with IC50s of 6.6 and 25.3 nM, respectively[1].
Formula: C24H24FN7O
References: [1]Toyn JH, et al., Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects. J Pharmacol Exp Ther. 2016 Jul;358(1):125-37.
CAS Number: 1263871-36-8
Molecular Weight: 445.49
Research Area: Neurological Disease
Solubility: 10 mM in DMSO
Target: γ-secretase