BpV(HOpic), CAS 722494-26-0

Product Description: BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity[1][2].

Applications: Cancer-Kinase/protease

Formula: C6H4K2NO8V

References: [1]Ponte CD, et, al. Pharmacological postconditioning protects against hepatic ischemia/reperfusion injury. Liver Transpl. 2011 Apr; 17(4): 474-82./[2]Zhou J,et, al. Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury. Sci Rep. 2017 Aug 25; 7(1): 9503./[3]Kim MS, et, al. Nanotherapeutics of PTEN Inhibitor with Mesoporous Silica Nanocarrier Effective for Axonal Outgrowth of Adult Neurons. ACS Appl Mater Interfaces. 2016 Jul 27; 8(29): 18741-53./[4]Schmid AC, et, al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 2004 May 21; 566(1-3): 35-8./[5]Zhang B, et, al. Silencing of miR-19a-3p enhances osteosarcoma cells chemosensitivity by elevating the expression of tumor suppressor PTEN. Oncol Lett. 2019 Jan; 17(1): 414-421./[6]Dimchev GA, et, al. Phospho-tyrosine phosphatase inhibitor Bpv(Hopic) enhances C2C12 myoblast migration in vitro. Requirement of PI3K/AKT and MAPK/ERK pathways. J Muscle Res Cell Motil. 2013 May; 34(2): 125-36./[7]Raffel N, et, al. The effect of bpV(HOpic) on in vitro activation of primordial follicles in cultured swine ovarian cortical strips. Reprod Domest Anim. 2019 Aug; 54(8): 1057-1063.

CAS Number: 722494-26-0

Molecular Weight: 347.24

Compound Purity: 98.0

Research Area: Cancer; Neurological Disease

Solubility: DMSO : 2.89 mg/mL (ultrasonic)/H2O : 50 mg/mL (ultrasonic;warming;heat to 60°C)

Target: PTEN

• Artikelnummer: MEXHY-128693-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-128693-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK