Bucladesine (sodium), CAS 16980-89-5

Product Description: Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium salt has anti-inflammatory activity and can be used for impaired wound healing[1][2][3][4].

Formula: C18H23N5NaO8P

Citations: Adv Sci (Weinh). 2021 Oct 31;e2100808./bioRxiv. 2024 Mar 31./Cell Commun Signal. 2022 Apr 12;20(1):52./Cell Stem Cell. 2021 Aug 5;28(8):1362-1379.e7./Cell Tissue Res. 2022 Feb 11./Ecotoxicol Environ Saf. 2022 Aug 17;243:113982./Eur J Pharmacol. 2022 Aug 28;932:175231./FASEB J. 2020 Oct;34(10):13376-13395./FASEB J. 2024 May 15;38(9):e23622./FEBS Lett. 2021 Oct 23./Front Microbiol. 2021 Aug 17;12:692693./Int J Mol Sci. 2022, 23(20), 12595./Int J Mol Sci. 2023 Feb 8;24(4):3398./Int J Mol Sci. 2023 Mar 7./J Assist Reprod Genet. 2024 Mar 25./J Bone Miner Metab. 2021 Apr 8./J Endocrinol. 2019 Sep 1;JOE-19-0284.R2./J Steroid Biochem Mol Biol. 24 September 2022, 106192./Pigment Cell Melanoma Res. 2023 Aug 9./Plants. 2023 Oct 24, 12(21), 3666./Proteome Sci. 2023 Oct 11;21(1):16./protocols.io. 2024 Jan 12./Reproduction. 2021 May 27;162(1):33-45./Toxins. 2021 Aug 22;13(8):585./Exp Ther Med. January 31, 2022.

References: [1]Salehi F, et al. Effect of bucladesine, pentoxifylline, and H-89 as cyclic adenosine monophosphate analog, phosphodiesterase, and protein kinase A inhibitor on acute pain. Fundam Clin Pharmacol. 2017 Aug;31(4):411-419./[2]Shimojo M, et al. The cholinergic gene locus is coordinately regulated by protein kinase A II in PC12 cells. J Neurochem. 1998 Sep;71(3):1118-26./[3]Sharifzadeh, M., et al., Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats. Eur J Pharmacol, 2007. 562(3): p. 212-20./[4]Mafune, E., M. Takahashi, and N. Takasugi, Effect of vehicles on percutaneous absorption of bucladesine (dibutyryl cyclic AMP) in normal and damaged rat skin. Biol Pharm Bull, 1995. 18(11): p. 1539-43./[5]Rundfeldt, C., et al., The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Arch Dermatol Res, 2012.

CAS Number: 16980-89-5

Molecular Weight: 491.37

Compound Purity: 99.48

Research Area: Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : ≥ 50 mg/mL

Target: Phosphodiesterase (PDE);PKA

• Artikelnummer: MEXHY-B0764-500
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0764-500
• Green Labware: Nein
• Verpackungseinheit: 500 mg
• Mengeneinheit: STK