Carboplatin (Standard), CAS 41575-94-4

Product Description: Carboplatin (Standard) is the analytical standard of Carboplatin. This product is intended for research and analytical applications. Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.

Formula: N/A

References: [1]Natarajan G, et al. Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum(II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited. Biochem Pharmacol. 1999 Nov 15;58(10):1625-9./[2]Banerji U, et al. An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models. Cancer Chemother Pharmacol. 2008 Oct;62(5):769-78./[3]Clark CC, et al. Enhancement of synthetic lethality via combinations of ABT-888, a PARP inhibitor, and carboplatin in vitro and in vivo using BRCA1 and BRCA2 isogenic models. Mol Cancer Ther. 2012 Sep;11(9):1948-58./[4]Dela Cruz FS, et al. A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. Genome Med. 2016 Oct 31;8(1):116./[5]Hall MD, Telma KA, Chang KE, et al. Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes. Cancer Res. 2014;74(14):3913-3922.

CAS Number: 41575-94-4

Molecular Weight: N/A

Research Area: Cancer

Target: Autophagy;DNA Alkylator/Crosslinker;DNA/RNA Synthesis

• Artikelnummer: MEXHY-17393R-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-17393R-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK